🔧 Engineered direct conversion of primary mouse embryonic fibroblasts into induced motor neurons

• Improved conversion yield to >1,000% and purity to >50% (x1,000 and x10 fold improvement)
• Worked with collaborators to engraft reprogrammed cells into mice in vivo
• Validated induced neurons using scRNA-seq and functional assays (MEA, Ca+2 signaling)

🧬 Designed and implemented genetic circuits in primary cells & iPSCs for reprogramming or gene editing

• Experience with recombinase-DNA circuits, modRNA, selection markers, protein degradation tools, tools for translational rate control, gene syntax design, viral transcript design (lenti, retro, AAV), miRNA circuits

📚 Led and contributed to diverse science communication projects

• Led 2 first-author publications; contributed as co-author on 2 manuscripts (both in review); wrote 2 first-author review articles
• Peer-reviewed several research articles and was featured as an exemplary peer-review in Cell Systems
• Organized new symposium for Boston mammalian synbio with 160 registered attendees in inaugural year